Macromolecule methylation

Across TCGA cell cohorts, RNA activity of the Macromolecule methylation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC1, TOLLIP, and GALE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macromolecule methylation activity versus KLHDC1 in BONE (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KLHDC1 →	-0.964	-0.163	.005	.001	3	6
URINARY_TRACT	TOLLIP →	-0.768	-0.225	.001	.001	3	6
LUNG_NSCLC_LUSC	GALE →	-1.611	-0.090	<.001	.007	3	5
BLOOD_Lymphoma	GALNT7 →	-1.440	-0.134	.007	.009	3	5
CNS	LRP11 →	-1.060	-0.130	<.001	<.001	3	4
CNS	AMACR →	-0.857	-0.136	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043414 vs KLHDC1 — BONE

Explore this scatter interactively →