Negative regulation of MAPK cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD12, CLC, and ELK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of MAPK cascade activity versus ANKRD12 in OV (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ANKRD12 →	+0.461	+0.113	.006	.002	3	3
OV	CLC →	+0.789	+0.100	<.001	<.001	3	3
OV	ELK3 →	+0.615	+0.115	.002	.003	3	3
OV	CD83 →	+0.591	+0.115	<.001	<.001	3	3
OV	KDR →	+0.581	+0.121	.005	.001	3	3
OV	LILRB2 →	+0.691	+0.134	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043409 vs ANKRD12 — OV

Explore this scatter interactively →