Negative regulation of MAPK cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENDOD1, RAB11FIP5, and RDH13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of MAPK cascade activity versus ENDOD1 in SOFT_TISSUE (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ENDOD1 →	-1.373	-0.201	.002	.004	3	5
BLOOD_Lymphoma	RAB11FIP5 →	-2.617	-0.282	<.001	<.001	3	5
LIVER	RDH13 →	-1.126	-0.204	<.001	.003	3	5
BLOOD_Lymphoma	PERM1 →	-1.115	-0.205	<.001	<.001	3	5
BLOOD_Lymphoma	ZNF594 →	+1.451	+0.274	.003	<.001	3	5
STOMACH	PLEKHN1 →	-1.678	-0.220	.009	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043409 vs ENDOD1 — SOFT_TISSUE

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