Negative regulation of MAP kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF3R, MIR223HG, and RAD51, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of MAP kinase activity activity versus CSF3R in LSCC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSF3R →	+1.089	+0.320	<.001	<.001	3	6
LSCC	MIR223HG →	+0.787	+0.188	<.001	<.001	3	5
GBM	RAD51 →	-0.552	-0.194	<.001	<.001	3	5
GBM	ZNF510 →	-0.407	-0.165	.002	.001	3	4
GBM	OIP5 →	-0.568	-0.246	<.001	<.001	3	4
GBM	CCNB1 →	-0.729	-0.146	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043407 vs CSF3R — LSCC

Explore this scatter interactively →