Negative regulation of MAP kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IAH1, SMARCAL1, and PRKCE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IAH1 grouped by Negative regulation of MAP kinase activity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IAH1 →	-0.768	-0.970	.002	<.001	3	4
CNS	SMARCAL1 →	-0.643	-1.538	<.001	<.001	3	4
CNS	PRKCE →	-0.951	-1.124	<.001	<.001	3	4
CNS	HBA1 →	+0.479	+0.890	.005	.002	3	4
BREAST	MSH2 →	+0.722	+0.680	.002	.004	3	3
OVARY	LIPG →	+2.413	+1.316	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IAH1 by Negative regulation of MAP kinase activity activity — CNS

Explore this box plot interactively →