Negative regulation of MAP kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCND3, FAM126A, and BICC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of MAP kinase activity activity versus CCND3 in BLOOD_Myeloma (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCND3 →	-0.972	-0.292	<.001	<.001	3	3
BREAST	FAM126A →	-1.538	-0.411	.002	.003	3	3
BREAST	BICC1 →	-1.576	-0.451	.003	.008	2	4
LUNG_NSCLC_LUAD	ADGRG1 →	+1.723	+0.212	.009	.003	3	3
LIVER	PEPD →	-1.211	-1.243	.003	.005	3	3
CNS	DNMT3A →	-1.220	-0.272	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043407 vs CCND3 — BLOOD_Myeloma

Explore this scatter interactively →