Positive regulation of MAP kinase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSD1L, CCNH, and ABRAXAS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of MAP kinase activity activity versus FSD1L in BRCA (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FSD1L →	-0.456	-0.607	.003	.005	3	4
BRCA	CCNH →	-0.381	-0.551	<.001	.001	3	4
BRCA	ABRAXAS1 →	-0.401	-0.597	<.001	<.001	3	4
LSCC	SLC34A2 →	+1.852	+0.563	<.001	.002	3	3
LSCC	HPGD →	+0.941	+0.689	<.001	<.001	3	3
BRCA	LYRM7 →	-0.398	-0.612	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043406 vs FSD1L — BRCA

Explore this scatter interactively →