Positive regulation of MAP kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of MAP kinase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPC2, PTTG3P, and TMPRSS11BNL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPC2 grouped by Positive regulation of MAP kinase activity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EPC2 →	-0.126	-0.541	.005	.006	3	4
STOMACH	PTTG3P →	-0.240	-0.251	<.001	<.001	3	4
STOMACH	TMPRSS11BNL →	-0.210	-0.195	.001	.001	3	3
STOMACH	DOCK9 →	+0.162	+0.326	.008	.002	3	3
UPPER_AERODIGESTIVE_TRACT	CBFA2T2 →	-0.210	-0.246	.005	.006	3	3
PANCREAS	APAF1 →	+0.211	+0.947	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPC2 by Positive regulation of MAP kinase activity activity — SKIN

Explore this box plot interactively →