Positive regulation of MAP kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFGE8, ANKRD13B, and BACH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of MAP kinase activity activity versus MFGE8 in OESOPHAGUS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MFGE8 →	-2.177	-1.020	.001	.006	3	4
LUNG_SCLC	ANKRD13B →	+1.343	+1.110	<.001	<.001	3	4
BLOOD_Leukemia	BACH2 →	-1.607	-0.428	.001	<.001	3	4
LUNG_NSCLC_LUSC	TBC1D16 →	+1.588	+1.780	.002	<.001	3	4
STOMACH	FUZ →	+3.002	+1.262	.001	<.001	3	4
BLOOD_Leukemia	ZNF516 →	+1.690	+0.342	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043406 vs MFGE8 — OESOPHAGUS

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