Regulation of MAP kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFCAB6, TEKT2, and C2orf15, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of MAP kinase activity activity versus EFCAB6 in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EFCAB6 →	-0.340	-0.323	.006	.007	3	3
BRCA	TEKT2 →	-0.703	-0.493	.008	<.001	3	3
CCRCC	C2orf15 →	-0.329	-0.142	.006	.001	3	3
HNSC	ATAD2B →	-0.501	-0.173	.001	.005	3	2
HNSC	ZNF30 →	-0.849	-0.229	.001	.002	3	2
HNSC	OR52E6 →	-0.468	-0.173	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043405 vs EFCAB6 — BRCA

Explore this scatter interactively →