Regulation of MAP kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VHL, DOCK9, and SHOC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VHL grouped by Regulation of MAP kinase activity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VHL →	+1.119	+0.268	.001	<.001	3	3
BLOOD_Leukemia	DOCK9 →	+2.143	+0.223	.004	.003	3	3
OESOPHAGUS	SHOC2 →	-0.504	-0.227	.008	.006	3	3
CNS	SMARCAL1 →	-0.686	-0.820	<.001	.001	3	3
STOMACH	CARF →	-0.750	-0.228	.002	.002	3	3
OESOPHAGUS	CNST →	-0.803	-0.266	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VHL by Regulation of MAP kinase activity activity — BLOOD_Leukemia

Explore this box plot interactively →