Regulation of MAP kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIB, NUCB2, and CAV2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of MAP kinase activity activity versus PPIB in BONE (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PPIB →	-1.638	-1.390	.007	.003	3	4
BLOOD_Lymphoma	NUCB2 →	-1.830	-0.594	<.001	.009	3	3
BREAST	CAV2 →	-3.039	-0.927	.001	<.001	3	3
BREAST	THEMIS2 →	-1.741	-1.110	.001	.001	3	3
BONE	DUSP11 →	-1.210	-1.806	.002	<.001	3	3
BREAST	TIAM2 →	-0.900	-0.993	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043405 vs PPIB — BONE

Explore this scatter interactively →