Skeletal muscle tissue regeneration

Across TCGA patient cohorts, RNA activity of the Skeletal muscle tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PACS2, PKD1P3, and SCAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle tissue regeneration activity versus PACS2 in UCEC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PACS2 →	+0.531	+0.261	<.001	<.001	3	5
LSCC	PKD1P3 →	+0.386	+0.149	.001	.006	3	5
LSCC	SCAP →	+0.465	+0.206	<.001	.002	3	4
UCEC	MAP1S →	+0.646	+0.269	<.001	.001	3	4
HNSC	CAND2 →	+0.826	+0.399	<.001	.004	3	4
PDAC	NR2F2 →	+0.470	+0.145	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043403 vs PACS2 — UCEC

Explore this scatter interactively →