Skeletal muscle tissue regeneration

Across TCGA cell cohorts, RNA activity of the Skeletal muscle tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK24, PSPC1, and GPHA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STK24 grouped by Skeletal muscle tissue regeneration-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	STK24 →	+0.926	+0.283	.008	.003	3	3
SKIN	PSPC1 →	-0.521	-0.208	.004	.001	3	3
SKIN	GPHA2 →	+0.032	+0.248	.009	<.001	3	3
LIVER	GTF2H2C →	-0.708	-0.305	.003	.004	2	4
UPPER_AERODIGESTIVE_TRACT	COX10 →	-1.200	-0.302	.001	.005	3	3
LIVER	ALKBH5 →	-1.097	-0.370	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STK24 by Skeletal muscle tissue regeneration activity — PANCREAS

Explore this box plot interactively →