Skeletal muscle tissue regeneration

Across TCGA cell cohorts, RNA activity of the Skeletal muscle tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC57, STX3, and GNG14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle tissue regeneration activity versus CCDC57 in URINARY_TRACT (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CCDC57 →	+1.048	+0.244	.008	.007	3	4
LUNG_SCLC	STX3 →	-1.393	-0.191	.006	.009	3	4
BLOOD_Leukemia	GNG14 →	+0.222	+0.232	<.001	.002	3	4
KIDNEY	TYMP →	-2.300	-0.368	<.001	.001	3	4
URINARY_TRACT	MRPL49 →	-0.688	-0.316	<.001	<.001	3	3
URINARY_TRACT	B3GALT5 →	+1.060	+0.253	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043403 vs CCDC57 — URINARY_TRACT

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