Steroid hormone mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Steroid hormone mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT4, LPIN1, and NTN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAAT4 grouped by Steroid hormone mediated signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PLAAT4 →	-2.671	-0.180	.002	.004	3	4
SOFT_TISSUE	LPIN1 →	-1.037	-0.230	.008	.007	3	4
BREAST	NTN4 →	-2.271	-0.179	<.001	<.001	3	4
OVARY	APLP2 →	-0.981	-0.183	.003	.003	3	4
LUNG_NSCLC_LUAD	C5orf15 →	-0.734	-0.150	.001	.004	2	4
BONE	PTS →	+0.735	+0.374	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAAT4 by Steroid hormone mediated signaling pathway activity — STOMACH

Explore this box plot interactively →