Steroid hormone mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Steroid hormone mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXD4, DNAJC1, and GLS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid hormone mediated signaling pathway activity versus MXD4 in BONE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MXD4 →	+1.278	+0.171	<.001	<.001	3	6
BLOOD_Leukemia	DNAJC1 →	+1.540	+0.143	<.001	.002	3	5
PANCREAS	GLS →	+0.814	+0.254	.006	.002	3	5
LUNG_SCLC	ANKRD13C →	+0.541	+0.167	<.001	.001	3	5
STOMACH	C17orf113 →	-0.535	-0.170	.007	<.001	3	5
SKIN	LYST →	+1.421	+0.147	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043401 vs MXD4 — BONE

Explore this scatter interactively →