Negative regulation of DNA binding

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR548AQ, IGF2BP2-AS1, and PPP3R1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA binding activity versus MIR548AQ in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR548AQ →	+1.835	+0.243	.001	.009	2	7
HNSC	IGF2BP2-AS1 →	+1.029	+0.318	<.001	<.001	3	6
PDAC	PPP3R1 →	+0.327	+0.203	<.001	<.001	3	5
BRCA	HMGA1 →	+0.916	+0.416	<.001	.006	3	5
HNSC	HMGA2 →	+1.172	+0.371	<.001	<.001	3	5
PDAC	USP14 →	+0.525	+0.213	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043392 vs MIR548AQ — HNSC

Explore this scatter interactively →