Negative regulation of DNA binding

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA binding pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC39A10, DDX5, and PKHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC39A10 grouped by Negative regulation of DNA binding-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC39A10 →	-0.103	-1.032	<.001	<.001	3	4
LUNG_NSCLC_LUAD	DDX5 →	+0.172	+0.844	.005	.001	3	4
LUNG_SCLC	PKHD1 →	-0.285	-0.325	.005	.005	3	3
OVARY	TRIM68 →	-0.225	-1.636	.001	.005	3	3
LUNG_NSCLC_LUAD	PI4KA →	-0.207	-1.114	.001	<.001	3	3
SKIN	RPS5 →	+0.165	+1.033	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC39A10 by Negative regulation of DNA binding activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →