Positive regulation of DNA binding

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA binding pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FN1, SPP1_S62, and CDKN1B_S10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA binding activity versus FN1 in GBM (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FN1 →	+0.675	+0.043	<.001	.001	3	5
GBM	SPP1_S62 →	+1.357	+0.047	<.001	<.001	3	5
COAD	CDKN1B_S10 →	-0.299	-0.024	.004	.009	3	4
COAD	CYP2S1 →	+0.501	+0.035	.001	.001	3	4
UCEC	IL1RAP_S557 →	+0.805	+0.045	.002	.008	3	4
COAD	IRS2_S577 →	+0.489	+0.035	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043388 vs FN1 — GBM

Explore this scatter interactively →