Positive regulation of DNA binding

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL8, IL1RN, and GJB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA binding activity versus CXCL8 in GBM (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CXCL8 →	+1.968	+0.123	.002	.007	3	5
LSCC	IL1RN →	+1.421	+0.182	<.001	<.001	3	5
LSCC	GJB2 →	+1.264	+0.124	.001	.004	3	5
UCEC	CXCL1 →	+2.004	+0.113	<.001	.007	3	5
LSCC	FAM25A →	+0.385	+0.097	.003	.006	3	5
LSCC	HCAR3 →	+1.106	+0.198	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043388 vs CXCL8 — GBM

Explore this scatter interactively →