Positive regulation of DNA binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPK, ANP32B, and NUP188, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA binding activity versus HNRNPK in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HNRNPK →	+0.684	+0.412	<.001	.002	2	8
UPPER_AERODIGESTIVE_TRACT	ANP32B →	+0.780	+0.371	<.001	.006	3	6
BREAST	NUP188 →	+0.909	+0.224	.001	.003	3	6
OVARY	CPNE7 →	+2.806	+0.369	<.001	.003	3	5
LUNG_NSCLC_LUSC	CREBZF →	+0.982	+0.422	<.001	.003	3	5
STOMACH	DBR1 →	+0.661	+0.393	.007	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043388 vs HNRNPK — UPPER_AERODIGESTIVE_TRACT

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