Mycotoxin metabolic process

Across TCGA patient cohorts, RNA activity of the Mycotoxin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HTATIP2, IRF2BPL, and MIEF1_S59, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mycotoxin metabolic process activity versus HTATIP2 in LUAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HTATIP2 →	+0.503	+0.142	<.001	<.001	3	5
LUAD	IRF2BPL →	-0.226	-0.122	.008	.001	2	6
CCRCC	MIEF1_S59 →	+0.384	+0.138	<.001	.001	3	5
HNSC	PARP4 →	+0.262	+0.104	.006	<.001	3	5
CCRCC	APEX1 →	-0.294	-0.126	<.001	.002	3	5
CCRCC	BCAR3 →	-0.374	-0.116	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043385 vs HTATIP2 — LUAD

Explore this scatter interactively →