Mycotoxin metabolic process

Across TCGA cell cohorts, RNA activity of the Mycotoxin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM59, RNF11, and GCSH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM59 grouped by Mycotoxin metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMEM59 →	-0.976	-1.596	<.001	<.001	3	4
SOFT_TISSUE	RNF11 →	-0.707	-1.451	<.001	<.001	3	4
SOFT_TISSUE	GCSH →	+0.878	+1.400	<.001	<.001	3	4
SOFT_TISSUE	CREB5 →	-2.857	-1.197	<.001	.005	3	4
SOFT_TISSUE	GNB2 →	-0.758	-1.473	.003	<.001	3	4
LUNG_NSCLC_LUAD	TMEM255B →	-1.025	-0.844	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM59 by Mycotoxin metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →