Mycotoxin metabolic process

Across TCGA cell cohorts, RNA activity of the Mycotoxin metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG9B, KDM1A, and APOBEC3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATG9B grouped by Mycotoxin metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ATG9B →	-0.164	-0.210	.002	.001	3	4
BREAST	KDM1A →	-0.235	-0.149	.005	.002	3	4
BLOOD_Myeloma	APOBEC3A →	+0.156	+0.228	.001	.004	2	5
LUNG_NSCLC_LUSC	NCAPD2 →	+0.148	+0.197	.003	.003	3	4
BONE	CDC123 →	+0.419	+0.443	.002	.001	3	4
PANCREAS	KRT1 →	-0.268	-0.256	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATG9B by Mycotoxin metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →