Positive regulation of memory T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of memory T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP2, WAS, and PTPRC, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of memory T cell differentiation activity versus LCP2 in UCEC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LCP2 →	-0.464	-0.085	<.001	.004	3	9
OV	WAS →	-0.495	-0.086	<.001	<.001	3	9
BRCA	PTPRC →	-0.592	-0.056	<.001	<.001	3	9
OV	PTPN7 →	-0.500	-0.061	<.001	<.001	3	9
UCEC	BTK →	-0.418	-0.086	.002	.001	3	8
UCEC	HCLS1 →	-0.526	-0.073	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043382 vs LCP2 — UCEC

Explore this scatter interactively →