Positive regulation of memory T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of memory T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYRM4, ELP1, and BCL7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of memory T cell differentiation activity versus LYRM4 in GBM (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LYRM4 →	-0.348	-0.076	.001	<.001	2	5
LSCC	ELP1 →	-0.266	-0.079	.002	.004	3	4
LUAD	BCL7A →	-0.480	-0.098	.001	.007	3	3
GBM	CAST →	+0.385	+0.042	<.001	.006	3	3
BRCA	VIPR1 →	+1.025	+0.097	<.001	.007	3	3
BRCA	ST3GAL5 →	+0.461	+0.096	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043382 vs LYRM4 — GBM

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