"Positive regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S107, SAMSN1_S23, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD8-positive, alpha-beta T cell differentiation" activity versus SAMSN1_S107 in UCEC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMSN1_S107 →	+0.966	+0.188	<.001	<.001	3	10
UCEC	SAMSN1_S23 →	+0.989	+0.142	<.001	<.001	3	10
OV	SASH3 →	+0.657	+0.143	<.001	<.001	3	10
GBM	SEPTIN1 →	+1.061	+0.111	<.001	<.001	3	10
BRCA	SERPINB9 →	+0.556	+0.067	<.001	<.001	3	10
OV	SPN_S368 →	+1.524	+0.153	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043378 vs SAMSN1_S107 — UCEC

Explore this scatter interactively →