"Positive regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, DOK3, and CD96, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD8-positive, alpha-beta T cell differentiation" activity versus ARHGAP9 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP9 →	+0.818	+0.467	<.001	.001	3	7
HNSC	DOK3 →	+0.688	+0.637	<.001	<.001	3	7
UCEC	CD96 →	+1.107	+1.064	<.001	<.001	3	7
HNSC	CD3G →	+0.909	+0.450	<.001	<.001	3	7
HNSC	CD7 →	+0.776	+0.461	<.001	.004	3	7
UCEC	TNFRSF1B →	+0.722	+0.751	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043378 vs ARHGAP9 — HNSC

Explore this scatter interactively →