"Positive regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRR1, RBBP8, and ZC3H8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRR1 grouped by "Positive regulation of CD8-positive, alpha-beta T cell differentiation"-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRR1 →	+1.077	+1.172	.005	.004	3	4
LARGE_INTESTINE	RBBP8 →	+0.718	+0.971	.008	.005	3	4
OVARY	ZC3H8 →	+0.917	+1.175	.001	<.001	3	3
OVARY	SLC8A1 →	-1.801	-1.148	.001	.001	3	3
LUNG_NSCLC_LUSC	GAL3ST4 →	+1.613	+1.492	.007	.001	3	3
OVARY	FAM133B →	+0.726	+1.105	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRR1 by "Positive regulation of CD8-positive, alpha-beta T cell differentiation" activity — LARGE_INTESTINE

Explore this box plot interactively →