"Positive regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LANCL1, DTD1, and BCL11B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD8-positive, alpha-beta T cell differentiation" activity versus LANCL1 in BLOOD_Leukemia (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LANCL1 →	+0.920	+0.299	<.001	<.001	3	2
BLOOD_Leukemia	DTD1 →	-2.824	-0.315	<.001	.003	3	2
BLOOD_Leukemia	BCL11B →	+2.131	+0.239	.002	<.001	3	2
BLOOD_Leukemia	DYRK3 →	+1.325	+0.231	<.001	.003	3	2
BLOOD_Leukemia	ENDOD1 →	+1.456	+0.246	<.001	<.001	3	2
BLOOD_Leukemia	JAKMIP1 →	+2.815	+0.394	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043378 vs LANCL1 — BLOOD_Leukemia

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