"Positive regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OSBPL9, MRPL13, and CYC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD8-positive, alpha-beta T cell differentiation" activity versus OSBPL9 in BLOOD_Leukemia (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OSBPL9 →	+0.595	+0.272	.003	.003	3	2
BLOOD_Leukemia	MRPL13 →	-0.371	-0.199	.004	.002	3	2
BLOOD_Leukemia	CYC1 →	-0.864	-0.267	<.001	<.001	3	2
BLOOD_Leukemia	HTATSF1 →	+0.527	+0.173	.003	.001	3	2
BLOOD_Leukemia	SF3B6 →	+0.207	+0.265	.002	.003	3	2
BLOOD_Leukemia	TRA2B →	+0.315	+0.205	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043378 vs OSBPL9 — BLOOD_Leukemia

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