"Regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB4, SLC4A2, and CBFB, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LILRB4 grouped by "Regulation of CD8-positive, alpha-beta T cell differentiation"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LILRB4 →	-0.356	-1.689	.004	<.001	3	10
BREAST	SLC4A2 →	-0.205	-1.282	.001	<.001	3	9
BLOOD_Leukemia	CBFB →	-0.686	-0.733	<.001	.003	3	8
CNS	ZBTB7B →	-0.112	-0.719	.001	.004	3	7
BLOOD_Myeloma	DLX2 →	-0.404	-1.264	.005	.005	3	5
BLOOD_Myeloma	PSG11 →	+0.480	+1.593	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LILRB4 by "Regulation of CD8-positive, alpha-beta T cell differentiation" activity — SOFT_TISSUE

Explore this box plot interactively →