"Regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAAF1, RPL34, and JCAD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAAF1 grouped by "Regulation of CD8-positive, alpha-beta T cell differentiation"-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PAAF1 →	-1.073	-1.579	<.001	<.001	2	5
LUNG_SCLC	RPL34 →	-0.853	-1.267	.007	.002	3	4
LUNG_NSCLC_LUSC	JCAD →	-3.083	-1.637	<.001	<.001	3	4
SKIN	ADNP →	+0.340	+0.957	.009	.002	2	4
SKIN	TRPA1 →	+0.749	+0.892	<.001	.002	3	3
SKIN	TMEM144 →	-0.991	-0.869	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAAF1 by "Regulation of CD8-positive, alpha-beta T cell differentiation" activity — URINARY_TRACT

Explore this box plot interactively →