"Regulation of CD8-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Regulation of CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB7B, CHTOP, and PYGO2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD8-positive, alpha-beta T cell differentiation" activity versus ZBTB7B in KIDNEY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZBTB7B →	+1.217	+0.183	<.001	<.001	2	15
LUNG_NSCLC_LUAD	CHTOP →	+0.593	+0.139	.003	.004	3	10
LUNG_NSCLC_LUAD	PYGO2 →	+0.713	+0.123	.001	.007	2	10
LIVER	APH1A →	+0.628	+0.183	.001	.006	3	9
BONE	ZNF862 →	+0.956	+0.130	.002	.007	3	9
BREAST	H3-3A →	+0.796	+0.139	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043376 vs ZBTB7B — KIDNEY

Explore this scatter interactively →