"CD8-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTRA4, C1QC, and C1QB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD8-positive, alpha-beta T cell differentiation" activity versus HTRA4 in CCRCC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HTRA4 →	+0.779	+0.681	<.001	<.001	3	7
GBM	C1QC →	+1.048	+0.541	<.001	<.001	3	6
GBM	C1QB →	+1.115	+0.527	<.001	<.001	3	6
GBM	PCED1B-AS1 →	+0.769	+0.479	<.001	<.001	3	6
GBM	APOBEC3H →	+0.441	+0.468	<.001	<.001	3	6
OV	FTH1P22 →	+0.464	+0.466	.002	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043374 vs HTRA4 — CCRCC

Explore this scatter interactively →