"CD8-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "CD8-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM14, TRAF3IP1, and PCBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD8-positive, alpha-beta T cell differentiation" activity versus RBM14 in LIVER (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RBM14 →	+0.790	+0.321	<.001	.001	3	6
PANCREAS	TRAF3IP1 →	+0.788	+0.342	<.001	.002	3	6
LIVER	PCBP1 →	+0.686	+0.355	.001	.002	3	5
LIVER	DNAJC11 →	+0.768	+0.359	<.001	<.001	3	5
LUNG_NSCLC_LUAD	DLG1 →	-0.783	-0.244	<.001	<.001	3	5
PANCREAS	CARNMT1 →	+1.025	+0.365	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043374 vs RBM14 — LIVER

Explore this scatter interactively →