"Positive regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC10A, ITGAX, and MYO1F, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell differentiation" activity versus CLEC10A in LAML (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	CLEC10A →	+2.149	+0.068	<.001	<.001	3	34
SCLC	ITGAX →	+1.876	+0.134	<.001	<.001	3	34
SCLC	MYO1F →	+1.799	+0.143	<.001	<.001	3	34
LAML	FGD2 →	+2.410	+0.102	<.001	<.001	3	34
SCLC	CLEC12A →	+1.148	+0.100	<.001	<.001	3	34
CHOL	GPR132 →	+1.450	+0.057	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043372 vs CLEC10A — LAML

Explore this scatter interactively →