"Positive regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and SAMSN1_S107, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell differentiation" activity versus RCSD1 in UCEC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCSD1 →	+0.615	+0.069	<.001	<.001	3	10
LSCC	RCSD1_S351 →	+0.658	+0.066	<.001	<.001	3	10
CCRCC	SAMSN1_S107 →	+0.967	+0.082	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.895	+0.065	<.001	<.001	3	10
OV	SASH3 →	+0.545	+0.063	<.001	<.001	3	10
LSCC	STK10 →	+0.454	+0.067	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043372 vs RCSD1 — UCEC

Explore this scatter interactively →