"Positive regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K1, SCIMP, and TAF5LP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell differentiation" activity versus MAP4K1 in LSCC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP4K1 →	+0.547	+0.552	<.001	<.001	3	8
LSCC	SCIMP →	+0.640	+0.865	<.001	<.001	3	8
LSCC	TAF5LP1 →	+0.915	+1.018	<.001	<.001	3	8
LSCC	SIRPG →	+0.784	+0.560	<.001	<.001	3	8
LSCC	ITGAL →	+0.867	+0.549	<.001	<.001	3	8
LSCC	SPN →	+0.886	+0.708	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043372 vs MAP4K1 — LSCC

Explore this scatter interactively →