"Positive regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGER2, PTPRF, and DCLRE1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTGER2 grouped by "Positive regulation of CD4-positive, alpha-beta T cell differentiation"-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PTGER2 →	-1.202	-1.203	.003	<.001	3	4
SKIN	PTPRF →	-0.961	-0.356	.009	.008	3	3
LUNG_NSCLC_LUAD	DCLRE1C →	-0.520	-1.131	.006	<.001	3	3
LUNG_NSCLC_LUAD	TXK →	-0.600	-1.230	<.001	<.001	3	3
SKIN	MIS18BP1 →	-0.510	-0.382	.001	.004	3	3
SKIN	NT5E →	-1.999	-0.368	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTGER2 by "Positive regulation of CD4-positive, alpha-beta T cell differentiation" activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →