"Positive regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, BRI3BP, and FOSL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell differentiation" activity versus ANXA1 in BLOOD_Lymphoma (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANXA1 →	+4.755	+0.758	<.001	.006	3	7
OESOPHAGUS	BRI3BP →	-0.578	-0.184	.006	.004	3	5
BREAST	FOSL1 →	+2.475	+0.507	.001	.005	3	5
BREAST	DPYD →	+2.492	+0.612	<.001	.001	3	5
BREAST	FNDC3B →	+1.018	+0.595	.001	<.001	3	5
BREAST	CCDC80 →	+2.495	+0.503	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043372 vs ANXA1 — BLOOD_Lymphoma

Explore this scatter interactively →