"Negative regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAR1B, NFATC2, and SIGLEC9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell differentiation" activity versus PRKAR1B in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRKAR1B →	-0.750	-0.411	<.001	<.001	3	4
COAD	NFATC2 →	+0.545	+0.338	<.001	.008	3	4
GBM	SIGLEC9 →	+0.726	+0.373	<.001	<.001	3	4
GBM	ANK3 →	-0.990	-0.422	<.001	<.001	3	4
GBM	ITGA5 →	+0.625	+0.340	.009	.003	3	4
GBM	CTSB →	+0.707	+0.364	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043371 vs PRKAR1B — GBM

Explore this scatter interactively →