"Negative regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPD, FOXP3, and HMGB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPD grouped by "Negative regulation of CD4-positive, alpha-beta T cell differentiation"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CPD →	+0.348	+1.247	.003	.006	3	6
SKIN	FOXP3 →	-0.159	-0.838	.004	.008	2	7
LIVER	HMGB1 →	-0.344	-0.996	.002	.004	3	5
CNS	SOCS5 →	-0.246	-0.981	.001	.004	3	5
BLOOD_Lymphoma	CBFB →	-0.490	-1.685	.003	.005	2	6
LUNG_NSCLC_LUSC	RUNX3 →	-0.221	-1.438	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPD by "Negative regulation of CD4-positive, alpha-beta T cell differentiation" activity — SOFT_TISSUE

Explore this box plot interactively →