"Negative regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, EMP3, and TIMP1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell differentiation" activity versus LGALS1 in LIVER (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LGALS1 →	+5.156	+0.163	<.001	.003	3	14
LUNG_NSCLC_LUSC	EMP3 →	+4.689	+0.113	<.001	<.001	3	14
BLOOD_Lymphoma	TIMP1 →	+4.347	+0.123	<.001	<.001	3	13
BLOOD_Lymphoma	ANXA1 →	+4.184	+0.118	<.001	<.001	3	13
LUNG_NSCLC_LUAD	FOSL1 →	+3.614	+0.131	<.001	<.001	3	12
LIVER	TNFRSF12A →	+1.786	+0.161	.003	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043371 vs LGALS1 — LIVER

Explore this scatter interactively →