"Negative regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, ATP8B3, and ZEB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell differentiation" activity versus LGALS1 in BLOOD_Lymphoma (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LGALS1 →	+4.297	+0.308	<.001	<.001	3	9
LUNG_NSCLC_LUAD	ATP8B3 →	+1.510	+0.217	<.001	<.001	3	8
BREAST	ZEB1 →	+1.607	+0.270	.004	.002	3	7
BLOOD_Lymphoma	ANXA1 →	+5.304	+0.279	<.001	<.001	3	7
LARGE_INTESTINE	PMP22 →	+2.142	+0.300	<.001	.006	2	8
BREAST	EMP3 →	+2.667	+0.204	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043371 vs LGALS1 — BLOOD_Lymphoma

Explore this scatter interactively →