"Regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN7, PARP15, and TNIP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD4-positive, alpha-beta T cell differentiation" activity versus PTPN7 in GBM (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPN7 →	+0.754	+0.895	<.001	<.001	3	6
GBM	PARP15 →	+0.589	+0.535	<.001	<.001	3	6
UCEC	TNIP3 →	+0.916	+0.227	.001	.005	3	5
GBM	TLR8 →	+1.275	+0.680	<.001	.001	3	5
UCEC	PTPN22 →	+0.686	+0.335	<.001	<.001	3	4
HNSC	CD3G →	+0.887	+0.532	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043370 vs PTPN7 — GBM

Explore this scatter interactively →