"CD4-positive or CD8-positive, alpha-beta T cell lineage commitment"

Across TCGA patient cohorts, RNA activity of the "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, WDFY4, and ADA2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" activity versus WAS in LSCC (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WAS →	+0.525	+0.091	<.001	<.001	3	10
LSCC	WDFY4 →	+0.560	+0.082	<.001	<.001	3	10
LSCC	ADA2 →	+0.619	+0.076	<.001	<.001	3	10
LSCC	CCDC88B_S597 →	+0.743	+0.090	<.001	<.001	3	10
UCEC	CORO1A →	+0.651	+0.060	.001	.004	3	10
LSCC	DOCK2 →	+0.658	+0.092	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043369 vs WAS — LSCC

Explore this scatter interactively →