"CD4-positive or CD8-positive, alpha-beta T cell lineage commitment"

Across TCGA patient cohorts, RNA activity of the "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1F, IKZF1, and LAPTM5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" activity versus MYO1F in LSCC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYO1F →	+0.934	+0.646	<.001	<.001	3	9
BRCA	IKZF1 →	+0.824	+0.503	<.001	.001	3	9
LSCC	LAPTM5 →	+0.830	+0.686	<.001	<.001	3	9
HNSC	WAS →	+0.704	+0.237	<.001	<.001	3	8
LSCC	DPEP2 →	+0.904	+0.731	<.001	<.001	3	8
HNSC	ARHGAP30 →	+0.571	+0.247	.002	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043369 vs MYO1F — LSCC

Explore this scatter interactively →