"CD4-positive or CD8-positive, alpha-beta T cell lineage commitment"

Across TCGA cell cohorts, RNA activity of the "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP11C, KLF3, and PTPRR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP11C grouped by "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ATP11C →	-0.185	-0.229	.006	.001	3	3
BLOOD_Leukemia	KLF3 →	+0.196	+0.254	.005	.009	3	3
LUNG_NSCLC_LUAD	PTPRR →	-0.202	-1.247	.009	.008	3	3
BONE	OPRD1 →	-0.229	-0.351	.005	.006	3	3
LUNG_NSCLC_LUAD	STARD5 →	-0.196	-1.015	.002	.002	3	3
STOMACH	NCLN →	+0.480	+0.620	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP11C by "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment" activity — BLOOD_Leukemia

Explore this box plot interactively →